In this paper, we provided evidence that probiotic bacteria signal NK cells to secrete high amounts of IFN-γ and TNF-α, which are substantially more than those induced by IL-2 and CD16 signaling; therefore, they are capable of providing augmented differentiation of the tumors which is important for the inhibition of tumor growth and metastasis and increased effectiveness of chemotherapy (4). Here, TNF is linked to neoplasm.