Treatment of OSCSCs with supernatants from IL-2 + anti-CD16mAb + sAJ2 in the presence of anti-TNF-α had slight enhancing effect on tumor growth, whereas supernatants obtained from anti-IFN-γ in combination with IL-2 + anti-CD16mAb + sAJ2-treated NK cells enhanced tumor cell growth substantially. This evidence concerns the gene IL2 and neoplasm.