To analyze the extent and significance of the regulatory role of IL-10 on untreated and activated NK cell in tumor differentiation, anti-IL-10mAb was added to NK cells in the presence of sAJ2 and/or monocytes, and their supernatants were used in the induction of differentiation, and resistance of OSCSCs to NK cell mediated lysis and secretion of IFN-γ (Figures 5A,B). The gene discussed is IL10; the disease is neoplasm.