Caspase-3 knockout mice are resistant to amebiasis and a pharmacological inhibitor of caspase-3, Ac-DEVD-CHO (N-acetyl-Asp-Glu-Val-Asp-aldehyde) reduces parasite cytotoxicity to host cells (Huston et al., 2000; Becker et al., 2010). The gene discussed is CASP3; the disease is amebiasis.