Our group has demonstrated several times that the signaling cascade via JAK2, RhoA, and Rho-kinase signaling is upregulated in liver fibrosis and located mainly in myofibroblast-like activated HSC (Zhou et al., 2006; Granzow et al., 2014; Klein et al., 2015). The gene discussed is RHOA; the disease is Hepatic fibrosis.