NFKB1 and gastric cancer: In SGC7901 gastric cancer cells, TGR5 ligand 23(S)-mCDCA suppresses gene expression of IP-10, interleukin (IL)-6, IL-1β, and MCP-1 mediated by NF-κB while GPBARA treatment suppresses gene expression of IP-10, IL-1β, and MCP-1 mediated by NF-κB (Figure 3A).