Specifically, EE induces a reduction of Aβ plaques (Jankowsky et al., 2005; Lazarov et al., 2005; Berardi et al., 2007; Li et al., 2013; Polito et al., 2014), of oxidative stress (Mármol et al., 2015) and increase in neurotrophins such as NGF and BDNF at the basal forebrain and other brain regions affected both in AD and DS (Ickes et al., 2000; Birch et al., 2013). Here, BDNF is linked to Alzheimer disease.