In recent years, treatment with (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol found in green tea, has gained attention as it has beneficial effects in AD mouse models possibly contributed by its antioxidant activity, free radical scavenging, iron chelating, anti-inflammatory effects, neuroprotection, and promotion of the non-amyloidogenic pathway of APP through ADAM10 maturation (Obregon et al., 2006; Kalfon et al., 2007; Rezai-Zadeh et al., 2008; Biasibetti et al., 2013; Kim et al., 2014). This evidence concerns the gene APP and Alzheimer disease.