MAPT and Alzheimer disease: FGF-2 levels are increased in AD (Stopa et al., 1990; Cummings et al., 1993) and it has been shown, in neural progenitor cells and in PC12 cells, that FGF-2 upregulation can increase GSK3 activity and induce the hyperphosphorylation of tau protein in various epitopes including S202, recognized by AT8 (Tatebayashi et al., 1999, 2003).