MRS2 and Alzheimer disease: Beyond its Hb-binding function, Hpt also acts as extracellular chaperone, by inhibiting amyloid beta (Aβ) fibril formation in vitro (Wilson et al., 2008; Yerbury et al., 2009), colocalizes with amyloid plaques in AD (Powers et al., 1981; Veerhuis et al., 2003; Yerbury et al., 2005), and was proposed as potential biomarker of AD (Thambisetty, 2010).