IL10 and Feingold syndrome: Genetically, the frequencies of the IL-10 592C allele and 1082A/-819C/-592C haplotype, that are reported to be inducers of IL-10, were significantly downregulated in patients with febrile seizures (FS) relative to normal controls, suggesting that IL-10 is genetically associated with FS and confers resistance to FS (Kurreeman et al., 2004; Ishizaki et al., 2009).