In addition, patients with chromosomal translocations at the MAPK10 locus present with epileptic seizures, motor and cognitive delays (Shoichet et al., 2006; Kunde et al., 2013) and a recent behavioral study by Reinecke et al. (2013) reported that Mapk10 knockout mice showed signs of anxiety as they were less active and did not exhibit normal navigational behavior during the Morris water maze task. Here, MAPK10 is linked to Anxiety.