While signaling cascades involved in long-term potentiation and memory are not affected by NFTs (Kuchibhotla et al., 2014) postmortem analysis of brains from people with mild cognitive impairment showed that cognitive symptoms correlate with pre-fibrillar tau rather than NFT’s (Vana et al., 2011; Mufson et al., 2014). The gene discussed is MAPT; the disease is Cognitive impairment.