Moreover, Rasier et al. (2007) demonstrated that transient exposure to EDCs (estradiol, o, p′-DDT) in early postnatal life can induce an early maturation of the pulsatile GnRH secretion and a subsequent early developmental reduction of LH response to GnRH, constituting a possible mechanism of the sexual precocity. Here, GNRH1 is linked to precocious puberty.