Furthermore, TARDBP (TDP-43) mutations are associated with sporadic and familial forms of ALS (Sreedharan et al., 2008; Van Deerlin et al., 2008) and were reported to form cytosolic protein aggregates in human postmortem tissues (Lee et al., 2012) and in iPSc-derived motor neurons (Egawa et al., 2012) of patients. Here, TARDBP is linked to amyotrophic lateral sclerosis.