SOD1 and amyotrophic lateral sclerosis: Golgi fragmentation has been found to be closely associated with other neuropathological hallmarks of ALS, such as cytoplasmic basophilic inclusions (Fujita et al., 2002), ubiquitin aggregates (Vlug et al., 2005), SOD1 aggregates (Fujita et al., 2000) and TDP-43 pathology (Fujita et al., 2008).