Mutations in the human COMP gene in a region that encoding the calmodulin-like repeat elements had been linked to the development of pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), which were dominantly inherited chondrodysplasias characterized by short stature and early-onset osteoarthrosis [27–30]. The gene discussed is COMP; the disease is multiple epiphyseal dysplasia.