BCL2 and neoplasm: Proteins of the Bcl‐2 family regulate the intrinsic mitochondrial cell death pathway with the family consisting of both pro‐ and anti‐apoptotic members.6 Over the past decade there has been significant interest in the PPIs of the Bcl‐2 family due to the role they play in apoptosis (we refer the reader to reference 7b for a detailed discussion of the Bcl‐2 family proteins).7 The ability of cancer cells to avoid apoptosis plays a large role in tumour progression and drug resistance.7a The Bcl‐2 family consists of both pro‐apoptotic proteins, anti‐apoptotic proteins and regulators.