The investigators also analyzed the numbers of several types of cells whose production is induced by tumors and which produce factors that inhibit the antitumor functions of T cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, T regulatory cells (CD4+CD 25+FOXP3+), regulatory B cells (CD1dhiCD5+), and NKT cells (Zhang and Meadows 2010; Zhang et al. 2012). The gene discussed is CD4; the disease is neoplasm.