CEACAM5 and neoplasm: Considering that patients with tumor deposits after neo-CRT had a TRG of 2 or 3 (minimal or no response) but no TRG of 0 (no viable cancer cells) [12], thus it was not unusual that tumor deposits positive patients in our study had significantly higher pretreatment CEA level, more advanced ypT and higher TRG than those negative ones.