Since for the three CXCR3 ligands CXCL9 CXCL10 and CXCL11 different and sometimes opposing function have been reported depending on the particular infection or pathology investigated [41], the different pattern of chemokine secretion among the alternative DC might promote their individual implementation in specific vaccine formulations depending on the particular clinical setting. The gene discussed is CXCL10; the disease is infection.