Deleterious mutations of COL7A1 have been associated with the development of aggressive SCCs in patients suffering from the recessive Hallopeau-Siemens dystrophic epidermolysis syndrome (HS-RDEB) [42] while its restoration delayed tumor cell dissemination in vitro and in vivo [43]. Here, COL7A1 is linked to recessive dystrophic epidermolysis bullosa.