SAFB1 mediated isoform-specific changes in ANK3 [47], ANKS1B [48], SAP97 (DLG1) [49], ADD2 [50], KIF16B [51, 52], and ELK3 [53], as well as in genes linked to the cytoskeleton and/or synaptic function and the aetiology of neurologic disease. This evidence concerns the gene KIF16B and nervous system disorder.