This sets these small HSPs apart from another family member, viz. HSPB5 which is found in MS lesions at increased levels not only in astrocytes but also in oligodendrocytes [10–12, 14, 15] (Additional file 1: Figure S1), and selectively accumulates in oligodendrocytes already at the stage of preactive lesions in the absence of infiltration or myelin damage. The gene discussed is CRYAB; the disease is myeloid sarcoma.