Our finding that HSPB1, HSPB5, HSPB6 and HSPB8 all fail to be induced in MS lesions in GM regions, including the GM part of leukocortical lesions, extends previous reports of striking pathological differences between WM and GM demyelination in MS [3, 4, 34]. The gene discussed is HSPB8; the disease is myeloid sarcoma.