UBE2E3 and brain neoplasm: In a similar set of experiments, but using syngeneic DEX from CRCL-pulsed DCs in the same murine brain tumor model, those DEX drove CBL (Cbl proto-oncogene, E3 ubiquitin protein ligase) and CBLB (Cbl proto-oncogene B, E3 ubiquitin protein ligase) signaling with AKT (protein kinase B) and ERK (extracellular regulated kinase) signaling in stimulated T cells [82].