This may or may not conflict with the induction of monocyte/macrophage M2 phenotypes (considered more tumor-promoting) by glioma TEX [146], but B16 TEX were regarded as inducers of DC maturation and CD4+ T cell stimulation, driving NFKB activation in RAW264.7 macrophage cells; however, those cells released a mixed bag of cytokines/chemokines with overall Th2/M2 phenotypes [147]. Here, CD4 is linked to neoplasm.