Taken together, it is persuasive that DPG inhibited fat absorption by the inhibition of pancreatic lipase, and reduced lipogenesis via AMPK activation and followed by fatty acid oxidation and inhibition of cholesterol synthesis, which might contribute the improvement of metabolic parameters and eventually leading to the anti-obesity effect in vivo. This evidence concerns the gene PRKAB1 and obesity due to melanocortin 4 receptor deficiency.