The polymorphism of CETP gene rs708272, rs3764261, rs1800775, rs711752, rs12149545 was closely related to the occurrence of dyslipidemia among the Xinjiang Uyghur and Kazakh ethnic groups; The frequencies of the rs708272 T alleles, rs3764261 T alleles rs711752 A alleles and rs12149545 A alleles are protective factors against dyslipidemia in the Uyghur and Kazakh population. Here, CETP is linked to metabolic syndrome.