Similarly, other up-regulated, NF-κB-sensitive miRNAs (such as the strongly and rapidly induced miRNA-146a) may be responsible for the promotion of amyloidogenesis (tetraspanin 12; TSPAN12) and/or defects in NF-κB regulation (IRAK-1, IRAK-2) in AD-affected tissues; these inducible, up-regulated miRNAs that down-regulate their target mRNAs also appear to form a self-perpetuating and pathogenic miRNA-mRNA signaling network, due in part to chronic NF-κB re-activation perhaps through the involvement of recurring deficits in IκB signaling [60,61,62,63,64,65,66,67,68,69,70,77,78,79,80,81]. The gene discussed is NFKB1; the disease is Alzheimer disease.