NFKB1 and Alzheimer disease: This family of six pathogenic miRNAs form a highly cooperative miRNA-mRNA signaling network that can in part explain the down-regulation of selective AD-relevant brain genes involved in amyloidogenesis, phagocytosis, the innate-immune response, synaptogenesis, neurotrophism and NF-κB signaling that also collectively support chronic inflammatory neurodegeneration (Table 1; Figure 1 and Figure 2).