Because the local concentrations of IFN-α, IFN-β, and TRAIL can be increased by genetically engineered MSCs, the activities of IFN-α, IFN-β, and TRAIL on suppression of tumor mass and animal survival are potentiated more effectively than are the activities of IFN-α, IFN-β and TRAIL used in a systematical treatment [50,173,188,189,190]. This evidence concerns the gene IFNB1 and neoplasm.