XIAP and central nervous system cancer: Moreover, Dasari et al. reported that downregulation of the anti-apoptotic inhibitor, X-linked inhibitor of apoptosis protein (XIAP), by human umbilical cord blood-derived mesenchymal stem cell (hUCBSC) treatment induced apoptosis of glioma cells and xenograft cells through the activation of caspase-3 and caspase-9 [45,46].