TOB1 and cancer: Our analysis of copy number alteration (CNA) in the TOB1 genomic locus using these TCGA human clinical cancer samples did not reveal any significant characteristics, which is very consistent with the previous reports that TOB1 mRNA could be degraded by miR-25 and that the TOB1 protein level is regulated by phosphorylation rather than by genomic copy number alteration [25,27].