Upon phosphorylation, the quick cellular turnover of TOB1 is mediated by SKP2, a substrate-targeting subunit of the SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complex as evidenced by the stabilization of the protein in both SKP2-null mouse fibroblasts and human cervical cancer (HeLa) cells lacking SKP2. This evidence concerns the gene SKP2 and cervical carcinoma.