An improved system of targeted nanoparticles with polyphenols displaying higher selectivity was presented by Catania and coworkers who showed that curcumin and resveratrol-containing liposomes coupled to anti-HER2 antibodies had enhanced cellular uptake, cytotoxic and antiproliferative effects mainly in the breast cancer cell line with the highest expression of HER2 [204]. The gene discussed is ERBB2; the disease is breast carcinoma.