In MCF-7 cell line, 10 and 40 μM resveratrol applied for 24 h reduced the cell surface expression of EGFR [143]; in MDA-MB-231 breast cancer cell line resveratrol suppressed EGF-mediated migration and matrix metalloproteinase (MMP)-9 levels [156]; in SK-BR-3 breast cancer cell line resveratrol mediated downregulation of HER2 gene [157]. This evidence concerns the gene MMP9 and breast cancer.