BRCA1 and breast carcinoma: Earlier in vivo result communicated the beneficial effect of genistein administrated to pre-pubertal Sprague-Dawley rats with DMBA induced tumors; accordingly, reduction in carcinoma incidence, reduction in tumor multiplicity, upregulation of BRCA1 mRNA was reported in correlation of genistein administration in rats with chemical induction of breast carcinoma [216,217].