Combination of cisplatin with genistein or tamoxifen with genistein decreased ROS production, apoptosis and autophagy in MCF-7 cells, but not in T47D and MCF-7 overexpressing ERβ, suggesting that in breast cancers with high ERα/ERβ ratio administration or consumption of genistein may be harmful [111]. Here, ESR2 is linked to breast carcinoma.