DNMT3A and breast cancer: Since several natural compounds (EGCG, genistein, withaferin A, curcumin and resveratrol) have been reported to decrease this elevated transcription of DNMT1, DNMT3a, and DNMT3b genes, the lower incidence of breast cancer among Asian women, who consume more of these natural compounds, may be related to the demethylation potential of these polyphenols [16,183].