DDIT3 and breast cancer: Moreover, the administration of 5, 10 and 20 μM apigenin decreased E26 transformation-specific domain-containing protein (Elk1), cAMP response element-binding protein (CREB) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in MDA-MB-231 breast cancer cells indicating that apigenin may act as an inhibitor of the transcription factors [149].