Exposure of breast cancer stem cells to 5 to 20 μM curcumin for 24 h inhibited migration and mammosphere formation, increased the expression of the epithelial markers cytokeratin 18 and 19, while decreasing the expression of Cyclin D1, avian myelocytomatosis viral oncoprotein homolog (c-myc), vimentin, MMP-2,-9 and the nuclear localization of β-catenin [194]. This evidence concerns the gene CCND1 and breast carcinoma.