Based on the anti-angiogenic property of delphindin, the purpose of the present study was first, to investigate the effect of delphinidin on in vivo tumor growth induced by B16-F10 melanoma cell xenograft in mice, to characterize the respective contribution of melanoma and endothelial cells in delphinidin effects and consequently to decipher how delphinidin interacts with the intracellular signalling pathways activated by VEGF in endothelial cells with respect to proliferation. This evidence concerns the gene VEGFA and melanoma.