We observed statistically significant downregulation of ITPR2 (p<0.001; mean relative expression 3.78 in LSCC samples and 1.7x107 for no tumor controls) and MAF (p<0.05; mean relative expression 310.14 in LSCC samples and 1.6x107 for no tumor controls) but not RGS5 (p>0.05; mean relative expression 1266.25 in LSCC samples and 1888.96 for no tumor controls) (Fig 1D). Here, RGS5 is linked to neoplasm.