Near the TBP-binding sites of human gene promoters, we found 22 obesity-related candidate SNP markers, including rs201381696 (obesity), rs200487063 and rs34104384 (both: obesity-caused hypertention) in the human gene (LEP) of leptin and rs183433761 (obesity resistance during a high-fat diet) in the human gene (GCG) of glucagon. Here, LEP is linked to obesity disorder.