LEP and obesity due to melanocortin 4 receptor deficiency: After that, we analyzed all unannotated SNPs in the [-70; -20] region (where all proven TBP-binding sites are located) in the only known promoter of the human LEP gene, which we selected due to Friedman's discovery that the LEP gene (encodes hormone leptin) is the "obesity gene": OB ≡ LEP [16] (Fig. S1, see Additional file 2).