LMAN2 and Stroke: (soluble mannose-binding lectin 2, synonym: protein C) contains the SNP marker (rs72661131) of variable immunodeficiency [110], preeclampsia [111], and stroke [112] caused by deficient expression of this gene as we have also predicted in silico [83] and confirmed under both equilibrium [79] and nonequilibrium [80] conditions in vitro.