By the same token, the minor variants -38g of rs200487063 and -30t of rs34104384 may cause a proportional increase in leptin production (by any tissues) and a proportional increase in the overall plasma leptin level, which is a known risk factor of hypertension as a complication of obesity [6,7]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.