In the Ath-HMDP, Gucy1b3 has a strong cis-eQTL in aorta (p = 9.7x10-6) as well as other tissues and its expression in aorta is negatively associated with atherosclerosis (r = 0.23, p = 0.04), consistent with human studies. The gene discussed is GUCY1B1; the disease is atherosclerosis.