In normoxia, autophagy is thought to be kept at a low level as Beclin1 (the mammalian ortholog of the yeast Atg6 gene) binds with low affinity to B-cell lymphoma-extra-large (Bcl-xL) and B-cell chronic lymphocytic leukemia/lymphoma 2 (Bcl-2) via its Bcl-2 homology 3 (BH3) domain [63, 64]. The gene discussed is BECN1; the disease is B-cell chronic lymphocytic leukemia.