One study revealed that apolipoprotein E (apoE) isoform apoE4 (epsilon4) participated in the induction of extreme hypertriglyceridemia, since the frequency of the apoE4/E3 phenotype in the patients with extreme hypertriglyceridemia was higher compared to those in the patients without extreme hypertriglyceridemia and control subjects [4]. The gene discussed is APOE; the disease is hypertriglyceridemia.