Therefore the use of VDR polymorphism as marker for tuberculosis susceptibility is under debate. MBL-2 variant alleles have been associated with lower serum MBL levels and contrasting associations for MBL-2 variant alleles and mycobacterial infection have been reported in different populations. VDR and MBL-2 polymorphisms' global and regional distribution, widely studied in several populations worldwide, varies significantly in each population, thus making it unique for the tuberculosis susceptibility studies. This evidence concerns the gene VDR and tuberculosis.