Therefore the use of VDR polymorphism as marker for tuberculosis susceptibility is under debate. MBL-2 variant alleles have been associated with lower serum MBL levels and contrasting associations for MBL-2 variant alleles and mycobacterial infection have been reported in different populations. VDR and MBL-2 polymorphisms' global and regional distribution, widely studied in several populations worldwide, varies significantly in each population, thus making it unique for the tuberculosis susceptibility studies. Here, MBL2 is linked to tuberculosis.