Herein, we demonstrated an association between anti-MUC1 IgG in the serum and recurrent disease; in spite of the fact that there was no relationship of lymph node positivity, tumor grade and Ki67 status between anti-MUC1 antibodies levels, there was a statistically significant association between anti-MUC1 IgA in NAF with LVI. The gene discussed is MUC1; the disease is neoplasm.