CACNA1D and posterior cortical atrophy: Interestingly, a previous study of DNA methylation in fusion-positive (n = 17) versus fusion-negative PCa (n = 20) found two larger hypomethylated regions, 500 bp in size, that were in the same genomic region as the hypomethylated CpG sites in the gene body of CACNA1D identified in the present study [23].