The two other top-ranked hypomethylated CpGs in this study were in the gene body of RAB40C and the 5′ UTR of GREM1. While RAB40C methylation was not correlated with gene expression, GREM1 showed higher mRNA transcript levels in fusion-positive PCa as compared to fusion-negative PCa. Here, GREM1 is linked to posterior cortical atrophy.