TNFSF10 and central nervous system cancer: For instance, As2O3-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor two [30] and another line of study demonstrated that As2O3 sensitizes human glioma cells to TRAIL-induced apoptosis via CCAAT/enhancer-binding protein homologous protein-dependent DR5 up-regulation [31].