There are limited reports about the association between Tp53 andXRCC1 polymorphisms and UL susceptibility, with conflicting results.Therefore we aimed to investigate the association between Tp53Arg72Pro, XRCC1 Arg399Gln and XRCC1 Arg194Trppolymorphisms and uterine leiomyoma women from southeastern Iran. The gene discussed is XRCC1; the disease is Uterine leiomyoma.