Despite the fact that there is no genetic association of Tau with AD, mutations of Tau cause different forms of neurodegenerative disease (e.g. Frontotemporal Dementia with Parkinsonism linked to Chromosome 17 (FTDP-17) [29, 51]), or increase the risk for FTD-spectrum disorders [40]. This evidence concerns the gene MAPT and neurodegenerative disease.