In Alzheimer Disease (AD), one observes two major aggregating proteins: Amyloid-beta (Aβ), which accumulates in the form of plaques mainly in the extracellular space and the microtubule associated protein Tau, which aggregates in the form of paired helical filaments (PHFs) intracellularly [59]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.