SRF and glioblastoma: Furthermore, Nunes-Xavier et al. [18] tested the effect of RNA silencing of Ets-2 on DUSP5 and DUSP6 mRNA levels and found no inhibitory effect for DUSP5 but only for DUSP6. In an extensive attempt to identify candidate transcription factor binding sites in genes regulated by specific signaling pathways in growth factor-stimulated human glioblastoma cell line, Tullai et al. [45] reported a predicted SRF binding sites in the DUSP5 promoter.