Also, 5 of the 69 IgE-associated DMPs were nominally associated with asthma in our persistently discordant MZ twins (cg08404225 (P = 0.003), cg05215575 (P = 0.014), cg09676390 (P = 0.019), cg25494227 (P = 0.02), cg17749520 (P = 0.029)). This evidence concerns the gene IGHE and asthma.