IGHE and asthma: These DMPs were not associated with asthma in twin pairs where the affected twin had remission of symptoms by age 18, although several IgE-associated DMPs were cg17890764 (P = 0.003), cg07374928 (P = 0.01) and cg11398517 (P = 0.028); these DMPs may be associated with IgE levels in childhood asthma which remits in early adulthood.