Studies of the cerebrospinal fluid (CSF) from patients with neurodegenerative disorders detected the differential expression of matrix Gla protein precursor, haptoglobin precursor in Alzheimer’s disease, APOM and DBP precursor in Parkinson’s disease, and nucleobindin-1 precursor in dementia with Lewy body30. The gene discussed is NUCB1; the disease is Parkinson disease.