THBS1 and Hepatic fibrosis: The highly connected hubs of both pathway-gene and PPI networks revealed 10 high degree genes (Table 4), and the levels of PDGFra, PDGFrb, PDGFb, PDGFd, COL1A1, COL1A2, COL5A2 and THBS1 expressions were significantly down-regulated by HQD treatment (Fig. 5), suggesting that these genes might be the potential molecular targets of HQD against liver fibrosis.