In addition, Liu et al. [11] have demonstrated that chitosan can activate AMPK phosphorylation and reverse the increase in liver PECK and phospho-38 protein expressions, and reverse the decrease in skeletal AKT protein phosphorylation and GLUT4 translocation in diabetic rats, indicating that chitosan ameliorates hyperglycemia through a decrease in liver gluconeogenesis and an increase in skeletal muscle glucose use. This evidence concerns the gene SLC2A4 and Hyperglycemia.