In FOCUS, comparing patients with HER2 strongly positive tumours (n = 18) versus those with no visible membrane staining (n = 826) gave a hazard ratio (HR) for OS of 0.81 [95% confidence interval (CI) 0.50, 1.32; the HR for PFS was 0.68, CI 0.42, 1.12]. Here, ERBB2 is linked to neoplasm.