The aqueous extract exhibited an opposite profile; it proved to be less apoptotic for the melanoma cells (A2058: 10.8 %, p < 0.05; HT168-M1: 13.1 %, p < 0.05) comparing to the control (A2058: 13.7 %; HT168-M1: 18.3 %) and had no effect on the number of the annexin V positive MRC-5 cells (30.6 vs. 31.2 %) (Fig. 5). This evidence concerns the gene ANXA5 and melanoma.