The most common mutations of the BRAF gene in melanoma occur within exon 15 codon 600 are the BRAFV600E(c.1799 T > A, p.Val600Glu), as detected in approximately 80% of mutated cases, and the BRAFV600K (c.1798_1799delinsAA, p. Val600Lys), detected in 5–30% of mutated cases10, 11. The gene discussed is BRAF; the disease is melanoma.