Originally hypothesized to be playing a role in SCC pathogenesis due to its location within a commonly amplified locus in patients with HNSCC (3q28) [15], ∆Np63 physically interacts with the NF-κB family member c-Rel to form a transcriptional complex that drives expression of IL-8, in human HNSCC cells [16,17,18]. This evidence concerns the gene REL and head and neck squamous cell carcinoma.