Because of the association between HH and HCC, and the proposed mechanisms by which iron deposition can lead to cellular injury and carcinogenesis, many studies have investigated the potential associations of HFE polymorphisms with various extrahepatic cancers, including colorectal cancer, hematological cancers, and estrogen-dependent cancers [16,17,18,19,20,21,22,23,24,25,26,27,28]. Here, HFE is linked to hepatocellular carcinoma.