Sandu O et al. [16] studied the role of AGEs in insulin resistance in C57/BL6 and db/db mice that were fed low- or high-AGE diet for 6 months and results showed elevated insulin levels (p < 0.001) with change in pancreatic islet structure in high-AGE fed animals as compared to low-AGE fed animals [16]. The gene discussed is INS; the disease is Insulin resistance.